Pegson In The Present . Com

Living in the Present…Aware of the Future…

Broccoli and Cabbage help protect lungs?

Hey Guys…Treatment iv 3 times a day along with nebs 3 times a day is bloody tough ..But more on that later..

If you like you vegies this is going to be easy but if not well tough titties…

Scientists at the University of Pennsylvania School of Medicine discovered that a dietary antioxidant found in such vegetables as broccoli and cauliflower protects cells from damage caused by chemicals generated during the body’s inflammatory response to infection and injury.

Research has showed that the antioxidant thiocyanate normally existing in the body protects lung cells from injuries caused by accumulations of hydrogen peroxide and hypochlorite, the active ingredient in household bleach. These potentially harmful chemicals are made by the body as a reaction to infection and injury. In addition, thiocyanate also protects cells from hypochlorite produced in reactions involving MPO, an enzyme released from germ-fighting white blood cells during inflammation

Lung injuries inflicted by excessive inflammation and recurring infection cause about ninety percent of CF patients’ symptoms and mortality. Although known as a chloride channel, CFTR also conducts thiocyanate ions, important because, in several ways, they can limit potentially harmful accumulations of hydrogen peroxide and hypochlorite, chemicals produced by the body to fight germs.

>>Where to find thiocyanates naturally? Cruciferous vegetables (broccoli, cabbage, cauliflower, turnip)

I’m not exactly sure if a supplement exists out there in the form of a tablet or powder so you guys might just have to start eating more veggies……



November 18, 2009 Posted by | All Posts, Articles | , , , , | 6 Comments

Should couples have cystic fibrosis test

ALL couples considering having a baby and women in early pregnancy should be offered cystic fibrosis screening after a five-year study detected 80 per cent of high-risk couples, its authors say.

Babies are screened at birth for the recessive genetic disease, which affects one in 3000, but routine carrier testing, which costs $250 for a full screening, is not offered and is not covered by Medicare or by health insurance.

Researchers tested 1000 couples considering pregnancy as well as women in early pregnancy (less than 14 weeks) at a public after-hours clinic in Newcastle between January 2003 and December 2007 by extracting DNA from mouthwash samples.

There is a one-in-400 chance of two carriers forming a relationship and a one-in-four chance of them having a child with the disease, which affects organs (especially the lungs and pancreas) by clogging them with thick, sticky mucus and considerably shortens life.

The study, published today in The Medical Journal of Australia, found 27 out of 730 people tested who had no family history were carriers. Of 270 people who had an affected family member or a child with cystic fibrosis, 126 were carriers. There were four couples deemed to be at high risk of having a child with cystic fibrosis, two couples with no family history.

One of the women was six weeks pregnant but further testing determined the child to be unaffected.

That couple, as well as two of the other couples, decided to use IVF and test before implantation for any future pregnancies.

The other couple fell pregnant six months later and decided to abort the foetus because it was affected.

One of the study’s authors, Louise Christie, a nurse and genetic counsellor at Hunter Genetics, said testing should be offered to everyone regardless of risk factors as it enabled couples to make an informed choice about reproduction.

”Cystic fibrosis is a common and severe disease that places considerable emotional and financial burden on affected individuals, their families and health services,” Ms Christie said.

”It would be beneficial for couples if it was funded by Medicare because from our research it does show that it would be valuable.”

Kristine Barlow-Stewart, the director of the Health Department’s centre for genetics education, said she supported testing but only where ethnicity or family history put people at a higher risk. ”Cystic fibrosis testing is not appropriate for all of the population,” Associate Professor Barlow-Stewart said.

She urged more GPs to ask patients about their ancestry because northern Europeans were more at risk.

The President of the Royal Australian and New Zealand College of Obstetricians and Gynaecologists, Ted Weaver, said the college recommended screening only for suspected carriers.

”Clearly the cost to the community of caring for a child with cystic fibrosis is considerable but then who’s to know what that child might achieve during their life that would bring economic benefit?” Dr Weaver said.

”I think it’s reasonable that people are offered the test but how that test is funded is really a matter for public debate.”

Sydney’s Westmead Children’s and Royal North Shore hospitals and a few private clinics do tests.

A laboratory manager at Royal North Shore’s laboratory and community genetics department, Anne Proos, said about 1000 people were tested there each year, 60 per cent of whom were pregnant.

The test picks up at least 70 per cent of cases for the most common gene mutation and more than 80 per cent of cases for the full screening.

What do you guys think? I personally think it should be compulsory to have the test no need having CF put upon more innocent souls.

November 9, 2009 Posted by | All Posts, Articles | , , , | Leave a comment

Cystic Fibrosis Sufferers Waiting for Lung Transplants May Soon Breathe a Sigh of Relief

Cystic Fibrosis Sufferers Waiting for Lung Transplants May Soon Breathe a Sigh of Relief

lung-transplantCystic fibrosis and other Lung disease patients who need new lungs are faced with a life-threatening problem: more than 80 percent of donated lungs can’t be used—they’re inflamed and barely functional [Scientific American]. Transplanted lungs also fail at a much higher rate than other transplanted organs, as they’re more likely to be rejected by the recipient’s body. But a new procedure that makes use of gene therapy may soon double or triple the supply of undamaged donated lungs, and may also improve their function once transplanted.

In both pre- and post-transplant lungs, the problem is inflammation caused by insufficient amounts of an immune molecule called IL-10. Donated lungs are immediately chilled on ice, which destroys any IL-10 that may remain in the lungs, allowing substantial damage to occur before the organ can be implanted. And a lack of the molecule after transplantation increases the likelihood that inflammation will damage the organ and induce rejection [Los Angeles Times].

To get around these problems, the researchers first built a domed chamber where pig lungs were kept at body temperature with a steady flow of oxygen and nutrients moving through them. That arrangement alone prevented substantial damage to the lungs. Next, in the gene therapy stage, the researchers used a harmless virus to bring a gene that produces IL-10 into the lung cells.

Lead researcher Shaf Keshavjee explains that the lungs that received the therapy had better blood flow and were more able to take in oxygen and expel carbon dioxide, the study showed. “It’s as if gene therapy turbocharges each individual cell to manufacture many more proteins in its own IL-10 factory,” Keshavjee said [Bloomberg]. The lungs also performed better and were better tolerated by the pigs who received the transplants, according to the study published in Science Translational Medicine.

The researchers also tried the first parts of the procedure on donated human lungs that were too damaged to transplant. The human lungs showed the same improvements in blood flow and respiration, suggesting that the therapy could repair lungs that would otherwise have been discarded, and could therefore increase the stock of available organs. Last year, 234 people in the U.S. died while waiting for a lung transplant…. Currently, more than 1,800 people in the U.S. are waiting for a lung [Bloomberg].

The human lungs weren’t transplanted into sick patients, but if Keshavjee’s experiments continue to go well human trials could begin in about a year. While questions about gene therapy remain–in some cases, the viral vectors used to transport genes have been found to cause serious side effects–the new approach has the potential to be a breath of fresh air.

October 30, 2009 Posted by | All Posts, Articles | , , , | Leave a comment